Machado-Joseph Disease is a rare inherited neurological disorder of the central nervous system. It is characterized by the slow degeneration of certain areas of the brain and slowly progressive clumsiness in the arms and legs, a staggering lurching gait that can be mistaken for drunkenness, difficulty with speech and swallowing, impaired eye movements sometimes accompanied by double vision or bulging eyes, and lower limb spasticity. Symptoms begin during adulthood.
The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.
PO Box 5801
Bethesda, Maryland 20824
Phone: 800-352-9424 or 301-496-5751
The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.
PO Box 27986
Golden Valley, MN 55427
Phone: 763-553-0020
Email: naf@ataxia.org
55 Kenosia Avenue
Danbury, CT 06810
Phone: 203-744-0100
Toll Free: 800-999-6673 (voicemail only)
Fact Sheet last updated on: 8/23/2024
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