Disability/Illness Description:

Machado-Joseph Disease is a rare inherited neurological disorder of the central nervous system. It is characterized by the slow degeneration of certain areas of the brain and slowly progressive clumsiness in the arms and legs, a staggering lurching gait that can be mistaken for drunkenness, difficulty with speech and swallowing, impaired eye movements sometimes accompanied by double vision or bulging eyes, and lower limb spasticity.  Symptoms begin during adulthood.


National Institute of Neurological Disorders & Stroke (NINDS)The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.
PO Box 5801
Bethesda, Maryland 20824
Phone: 800-352-9424 or 301-496-5751

National Ataxia Foundation (NAF)The National Ataxia Foundation is dedicated to improving the lives of persons affected by ataxia through support, education, and research.
2600 Fernbrook Lane, Suite 119
Minneapolis, MN 55447
Phone: 763-553-0020
Email: naf@ataxia.org

National Organization for Rare Disorders, Inc. (NORD)
55 Kenosia Avenue
Danbury, CT 06810
Phone: 203-744-0100
Toll Free: 800-999-6673 (voicemail only)
Fax: 203-798-2291

Other Information:

Machado-Joseph Disease – National Institute of Neurological Disorders and Stroke

Machado-Joseph Disease – National Organization for Rare Disorders

Machado-Joseph DiseaseBrainFacts.org


Fact Sheet last updated on: 4/14/2020